Rejoinder: Response-Adaptive Randomization in Clinical Trials
نویسندگان
چکیده
منابع مشابه
Practical Bayesian Adaptive Randomization in Clinical Trials
While randomization is the established method for obtaining scientifically valid treatment comparisons in clinical trials, it sometimes is at odds with what physicians feel is good medical practice. If a physician favors one treatment over another based on personal experience or published data, it may be more appropriate ethically for that physician to use the favored treatment, rather than enr...
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BACKGROUND AND PURPOSE A response-adaptive randomization (RAR) trial design actively adjusts the ratio of participants assigned to each trial arm, favoring the better performing treatment by using outcome data from participants already in the trial. Compared with a standard clinical trial, an RAR study design has the potential to improve patient participation in acute stroke trials. METHODS T...
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Increased survival is a common goal of cancer clinical trials. Owing to the long periods of observation and follow-up to assess patient survival outcome, it is difficult to use outcome-adaptive randomization in these trials. In practice, often information about a short-term response is quickly available during or shortly after treatment, and this short-term response is a good predictor for long...
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Accordingly to FDA draft guidance (2010), adaptive randomization (e.g. responseadaptive (RA) randomization) has become popular in clinical research because of its flexibility and efficiency, which also have the advantage of assigning fewer patients to inferior treatment arms. The RA design based on binary outcome is commonly used in clinical trial where “success” is defined as the desired (or u...
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ژورنال
عنوان ژورنال: Statistical Science
سال: 2023
ISSN: ['2168-8745', '0883-4237']
DOI: https://doi.org/10.1214/23-sts865rej